Fetal programming of coronary heart disease.
نویسنده
چکیده
People who develop coronary heart disease grow differently from other people both in utero and during childhood. Slow growth during fetal life and infancy is followed by accelerated weight gain in childhood. Two disorders that predispose to coronary heart disease, type 2 diabetes and hypertension, are preceded by similar paths of growth. Mechanisms underlying this are thought to include the development of insulin resistance in utero, reduced numbers of nephrons associated with small body size at birth and altered programming of the micro-architecture and function of the liver. Slow fetal growth might also heighten the body's stress responses and increase vulnerability to poor living conditions in later life. Coronary heart disease appears to be a developmental disorder that originates through two widespread biological phenomena, developmental plasticity and compensatory growth.
منابع مشابه
Maternal and Fetal Outcomes in Pregnant Women with Cardiac Diseases Presenting to Shariati Hospital Cardiovascular Department from 21st March 2017 to 20th March 2018
Background: Cardiac diseases are considered as major cause of maternal mortality during pregnancy and account for about 10% of all maternal mortalities. Cardiac diseases cause complications for both mother and fetus. In this study, we evaluated the effects of cardiac diseases on pregnancy and vice versa. Three groups of complications were examined: complication of maternal heart (serious and li...
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Low birthweight is now known to be associated with increased rates of coronary heart disease and the related disorders stroke, hypertension and non-insulin dependent diabetes. These associations have been extensively replicated in studies in different countries and are not the result of confounding variables. They extend across the normal range of birthweight and depend on lower birthweights in...
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عنوان ژورنال:
- Trends in endocrinology and metabolism: TEM
دوره 13 9 شماره
صفحات -
تاریخ انتشار 2002